• Applied Neuroinflammation Research with CHI3L1-IN-5 (Compoun

  2026-05-13

  CHI3L1-IN-5 (Compound Z17) uniquely enables researchers to block CHI3L1-mediated NF-κB inflammatory signaling and restore astrocyte function in Alzheimer’s models. This guide translates recent structural and pharmacological advances into actionable workflows, troubleshooting, and comparative advantages for neurodegeneration research.

• RG108: Precision DNA Methyltransferase Inhibitor for Epigene

  2026-05-13

  RG108 stands out as a potent, non-nucleosidic DNA methyltransferase inhibitor, enabling precise and reversible epigenetic modulation in both cancer research and stem cell differentiation workflows. Its unique mechanism, supported by robust experimental data, positions RG108 as a leading tool for researchers aiming to reactivate silenced genes and interrogate DNA methylation dynamics with confidence.

• Z-VDVAD-FMK: Advancing Caspase-2 Pathway Inhibition in Antiv

  2026-05-12

  Explore how Z-VDVAD-FMK, a potent caspase-2 inhibitor, enables advanced dissection of apoptosis and antiviral pathways. This in-depth article connects mechanistic insights with novel applications, offering a unique perspective beyond cancer research.

• Biotin-16-UTP: Enabling Next-Gen RNA Interactomics in HCC

  2026-05-12

  This thought-leadership article explores the mechanistic and translational impact of biotin-labeled uridine triphosphate—specifically APExBIO’s Biotin-16-UTP—in advancing RNA detection, purification, and interactome mapping, with a spotlight on lncRNA RNASEH1-AS1 in hepatocellular carcinoma (HCC). Integrating cutting-edge research and workflow recommendations, the article provides strategic guidance for translational researchers seeking to bridge molecular insights with clinical innovation.

• Thioguanine: Mechanistic Innovations in Antitumor and Antivi

  2026-05-11

  Explore Thioguanine’s dual mechanisms as an antitumor and antiviral agent, with a focus on its unique inhibition of DNA methyltransferase 1 and EV71 replication. This article offers fresh, mechanistic insights for advanced assay design and clinical translation.

• DGLA-Induced Ferroptosis via ACSL4 Rewires Lipid Metabolism

  2026-05-11

  This study uncovers how exogenous dihomo-γ-linolenic acid (DGLA) induces ferroptosis in acute myeloid leukemia (AML) cells through ACSL4-mediated lipid metabolic reprogramming. The findings highlight a promising metabolic vulnerability in AML, offering new avenues for overcoming chemotherapy resistance.

• Probing Therapeutic Peptide Aggregation with 1H NMR and AA-M

  2026-05-10

  This study systematically examines the aggregation behavior of structurally related therapeutic peptides, including degarelix, using 1H NMR spectroscopy and all-atom molecular dynamics simulations. The findings clarify how subtle sequence differences and counterion interactions influence aggregation, offering methodological advances for peptide drug development and formulation.

• Excessive Calpain Impairs Offspring Cognition via BDNF/TrkB

  2026-05-09

  This study reveals that maternal non-obstetric surgery during pregnancy triggers excessive calpain activation in the developing rat hippocampus, leading to BDNF/TrkB pathway dysregulation and impaired cognitive outcomes in offspring. Pharmacological calpain inhibition with MDL 28170 or TrkB pathway stimulation partially rescues neuronal structure and function, highlighting new avenues for neuroprotection research.

• Sodium Ascorbate: Applied Workflows for Cancer Cell Assays

  2026-05-09

  Sodium Ascorbate, the mineral salt form of ascorbic acid, enables reproducible induction of intracellular ROS and selective necrotic tumor cell death, advancing glioblastoma multiforme research and broader cancer models. Here, we detail data-driven protocols, real-world troubleshooting, and how APExBIO’s Sodium Ascorbate uniquely addresses experimental challenges in oncology workflows.

• Hippo Signaling Modules Govern Hepatobiliary Cell Maturation

  2026-05-08

  This study uncovers how two independent Hippo pathway modules, HPO1 and HPO2, distinctly regulate the maturation and fate of hepatocytes and cholangiocytes in mouse liver development. By integrating spatial transcriptomics and advanced imaging, the authors reveal stage- and cell type-specific Hippo signaling control, reshaping our understanding of liver development and regeneration.

• Hippo Signaling Modules Govern Hepatobiliary Cell Fate and M

  2026-05-07

  This study reveals how spatially and temporally restricted Hippo signaling modules (HPO1 and HPO2) distinctly regulate the fate and maturation of hepatocytes and cholangiocytes in mouse liver development. The findings clarify the pathway’s nuanced role as a developmental checkpoint and suggest new approaches for dissecting cellular plasticity in liver regeneration and disease.

• Structural Insights into TRPM3 Modulation by Neurosteroids a

  2026-05-07

  Yin et al. provide cryo-EM structures elucidating how neurosteroids and the anticonvulsant primidone regulate the TRPM3 ion channel. Their findings clarify binding sites and gating mechanisms, offering a molecular basis for developing targeted therapies for pain and TRPM3-linked neurodevelopmental disorders.

• MLKL Polymerization Drives Lysosomal Membrane Permeabilizati

  2026-05-06

  This study uncovers how MLKL polymerization at lysosomal membranes initiates lysosomal membrane permeabilization (LMP), leading to cathepsin B release and necroptotic cell death. The findings clarify a key mechanistic link in regulated necrosis and provide new experimental entry points for dissecting cell death pathways.

• Apicidin as a Histone Deacetylase Inhibitor: Applied Workflo

  2026-05-06

  Harnessing Apicidin’s selectivity for HDAC3 and HDAC6, researchers can dissect chromatin regulation, cancer proliferation, and oocyte maturation at unprecedented resolution. This article translates the latest peer-reviewed findings and bench workflows into practical, data-driven protocols—empowering advanced labs to maximize Apicidin’s potential as an anti-proliferative and anti-angiogenesis compound.

• LG 101506: Precision RXR Modulation for Translational Oncolo

  2026-05-05

  This thought-leadership article explores how LG 101506, a synthetic RXR modulator from APExBIO, empowers translational researchers to interrogate nuclear receptor signaling and immune modulation in cancer models. By synthesizing mechanistic insight and recent evidence on immune checkpoint regulation in triple-negative breast cancer (TNBC), we provide a strategic roadmap for leveraging RXR pathway modulation to address key challenges in immunometabolic and oncology research. The article bridges rigorous experimental design, clinical relevance, and emerging perspectives on RXR-driven disease modeling.

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